HIV drug stabilizes disease progression in metastatic colorectal cancer: Using reverse transcriptase inhibitors raises the possibility of a new therapeutic strategy in cancer.

Many cancers exhibit high levels of the reverse transcriptase enzyme. Single-agent lamivudine, a reverse transcriptase inhibitor, stopped disease progression in over 25% of patients with fourth-line refractory metastatic colorectal cancer. These results provide evidence for the evaluation of reverse transcriptase inhibitors as a new class of anti-cancer drugs.

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