Mechanism of bacterial toxins in deadly attacks: Cryo-EM and protein NMR 3D snapshots reveal sophisticated mechanism of action of a bacterial Tc toxin

A harmful and often deadly substance made by bacteria, a bacterial toxin manipulates host cell functions and disrupts vital cell processes in a living organism. Bacterial toxins hit host organisms where it hurts most, promoting infection and diseases in animals and humans. New findings not only reveal how the deadly cargo of the Tc toxin drives the collapse of the cell’s cytoskeleton but provide an explanation of the toxin’s high efficiency.

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